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KMID : 0606920110190030342
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Biomolecules & Therapeutics
2011 Volume.19 No. 3 p.342 ~ p.347
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Anticonvulsant Effect of Artemisia capillaris Herba in Mice
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Woo Tae-Seon
Yoon Seo-Young
Pena Ike Campomayor dela
Choi Ji-Young
Lee Hye-Lim
Choi Yoon-Jung
Lee Yong-Soo
Ryu Jong-Hoon
Choi Jae-Sue
Cheong Jae-Hoon
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Abstract
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In the present study, the anticonvulsant effects of Artemisia capillaris Herba (AC) and its major constituent, esculetin (ECT), were tested and the mechanism studied. Locomotion, Myorelaxation, motor coordination and electroshock seizure experiment were conducted in mice. To identify the anticonvulsant mechanism effect of this drug, chemical-induced seizure in mice and the ionic movement in neuroblastoma cells were also observed. The ethanol extract of AC was orally administered to mice 30 min. prior to testing and ECT was intraperitoneally injected. AC and ECT treatment did not change locomotor activities as well as activities on the rota-rod, which indicates that they did not cause a sedative and myorelaxation effect. AC and ECT treatment increased threshold of convulsion induced by electroshock. AC treatment also inhibited convulsion induced by pentylenetetrazole. In the case of strychnine however, only high dose of AC treatment inhibited convulsion. AC and ECT treatment increased the Cl?infl ux into the intracellular area in a dose-dependent manner. On the other hand, bicuculline, a GABA antagonist, inhibited the Cl?infl ux induced by AC and ECT. These results indicate that ECT induces the anticonvulsive effect of AC extract through the GABAergic neuron.
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KEYWORD
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Artemisia capillaris, Esculetin, Anticonvulsion, Seizure, GABA
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